Form Equals Function

This mantra defines our research philosophy, guiding our exploration of immune biology through advanced next-generation pathology techniques.

Histopathology offers a unique opportunity to examine the intricate spatial organization of cells,

revealing their architecture and the dynamic interactions that shape their function.
Immune cells and their targets exemplify this crosstalk, continuously influencing each other and adapting their spatial architecture and phenotypic profiles in response to microenvironment modulation.

At the core of our work is the characterization and granular analysis of these complex relationships,

as we strive to define further how form dictates function in both health and disease conditions.

iREACT

Project Lead: A. Gambella

Green-Path

Project Lead: F. Grillo

LIDO

Project Lead: L. Mastracci

GEDi-Path

Project Lead: A. Gambella

Green-Path explores how diagnostic and research pathology can evolve toward environmental sustainability without compromising diagnostic accuracy, patient safety, or scientific quality.

This project promotes practical strategies to reduce the environmental footprint of surgical pathology, including energy efficiency, chemical stewardship, solvent recovery, waste reduction, responsible use of consumables, and sustainable digital transformation.

At GIPC, Green-Path reflects our commitment to integrating environmental responsibility into next-generation pathology as a natural extension of quality, innovation, and long-term healthcare sustainability.

Interested? See also: Gambella A, Pigozzi S, Paudice M, Fiocca R, Mastracci L, Grillo F. "Green-path": planting seeds for environmental sustainability in diagnostic and research surgical pathology. Virchows Arch. 2026 Apr 25. doi: 10.1007/s00428-026-04537-8. Epub ahead of print. PMID: 42032136.

Ideas on Paper

Our contribution to next-generation pathology

2026

Automated paraffin embedding of tissue samples significantly reduces overall workflow time in routine pathology practice. Pathologica. 2026 Feb;118(1):30-37. doi: 10.32074/1591-951X-1773.
"Green-path": planting seeds for environmental sustainability in diagnostic and research surgical pathology. Virchows Arch. 2026 Apr 25. doi: 10.1007/s00428-026-04537-8.
“1 + 1 = 3”: The Added Value of Combining Immunohistochemistry and Dual-Probe Chromogen In Situ Hybridization to Improve HER2 Status Evaluation. Laboratory Investigation. Volume 106, Issue 6, 2026, 106125, doi: 10.1016/j.labinv.2026.106125.
Pre-analytical Determinants of Patient Eligibility for Immune Checkpoint Inhibitors Revealed by Quantitative PD-L1 Analysis. Laboratory Investigation. 2026 May 22:106138. doi: 10.1016/j.labinv.2026.106138. Epub ahead of print. PMID: 42176954.